Dementia and Sleep

How Does Dementia Change Sleep Patterns?

Circadian rhythm is a collection of physical and psychological processes that guide our sleep-wake cycle by responding to indicators in our environment. People with dementia experience fundamental changes in their circadian rhythm that work against getting quality sleep on a regular schedule.

The suprachiasmatic nucleus (SCN) is the part of the brain that serves as our internal clock and responds to cues, such as light, to indicate when we should be alert and when we should feel sleepy. Individuals who have Alzheimer’s disease—the most common type of dementia—often have damaged cells in the SCN Trusted Source Elsevier Elsevier is a publishing company that aims to help researchers and health care professionals advance science and improve health outcomes for the benefit of society. View Source and decreased cellular activity in this part of the brain. The result of this dysfunction is that patients are often unable to follow a 24-hour sleep-wake cycle and instead sleep excessively during the day and sleep much less at night.

Additionally, dementia is associated with changes in sleep structure. When we sleep, our bodies cycle through a series of sleep stages, from light sleep (stages 1 and 2), to deep sleep (stage 3 or slow-wave sleep), and then dream sleep (also called rapid eye movement or REM sleep). Slow-wave sleep and REM sleep are critical parts of how sleep works to restore the body and mind. People with dementia spend less time Trusted Source National Center for Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source  in slow-wave sleep and REM sleep and more time in the earlier stages of sleep. This reduction of deep sleep and REM sleep can worsen as dementia progresses.

Normal Sleep Pattern Changes in Older Age

Research has documented a number of sleep changes that occur in healthy aging adults. These include bedtimes and wake times shifting Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source to an earlier hour, taking longer to fall asleep once in bed, experiencing fragmented sleep, sleeping fewer hours per night, and spending less time in slow-wave and REM sleep. Although these changes parallel some of the sleep challenges seen in people with dementia, the sleep pattern changes in dementia patients tend to be more dramatic and disruptive.

Common Sleep Disorders in People With Dementia

People with dementia are frequently affected by sleep disorders. The following sleep disorders are found most often in older adults, but they are seen at even higher rates in people with dementia.

• Restless legs syndrome (RLS): RLS is characterized by an overwhelming desire to move the legs, especially at night. RLS is common in people with a type of dementia called Lewy body dementia.
• Periodic limb movement disorder (PLMD): PLMD causes uncontrollable movements of the arms and/or legs at night. Many patients with PLMD also have RLS.
• Obstructive sleep apnea (OSA): OSA is a condition marked by nighttime airway collapse leading to brief lapses in breathing. OSA is particularly common with Alzheimer’s disease, occurring in 40% of patients. Having OSA also increases one’s risk of developing dementia.
• REM sleep behavior disorder: REM sleep behavior disorder causes individuals to act out their dreams, sometimes in dangerous ways. It is most often found in individuals with Lewy body dementia and is sometimes the first symptom Trusted Source Medline Plus MedlinePlus is an online health information resource for patients and their families and friends. View Source that arises with this type of dementia.
• Depression: Although depression is a mood disorder, it is associated with insomnia and other sleep disturbances. Depression is common in people with dementia, and it is seen at increasing rates Trusted Source National Center for Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source as dementia progresses to more severe stages.

Other Sleep Issues in People With Dementia

“Sundowning” is a phenomenon in which individuals with dementia experience increased agitation Trusted Source National Institutes on Aging (NIA) NIA leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. View Source later in the day and in the evening. The symptoms of sundowning include confusion, anxiety, wandering, and yelling. Sundowning can contribute to insomnia and other sleep problems when these behaviors continue into the night. Possible causes of sundowning include the circadian rhythm changes that occur in dementia, as well as fatigue, depression, and pain.

People with dementia may also talk, yell, or cry out at night if they cannot sleep. Some dementia patients have a tendency to wander away Trusted Source National Institutes on Aging (NIA) NIA leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. View Source from their homes, which can be especially dangerous at night. In dementia patients with REM sleep behavior disorder Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source , shouting, grabbing, jumping, and other behaviors are related to dream enactment during sleep.

How Does Sleep Affect Dementia Risk?

Experts suggest that sleep and dementia may share a bidirectional relationship Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source . This means that while sleep could affect dementia risk and symptoms, the presence or absence of dementia also affects sleep quality. For example, one of the first Alzheimer’s disease symptoms in the brain is the accumulation of a protein called amyloid-beta, which eventually forms clumps called amyloid plaques. Animal studies and a small study in people Trusted Source National Institutes of Health (NIH) The NIH, a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives. View Source have shown sleep deprivation to increase the levels of amyloid-beta in the brain. At the same time, Alzheimer’s patients with amyloid plaques have been shown to have worse sleep quality than Alzheimer’s patients who do not have amyloid plaques.

Additionally, sleep is known to be critical for our cognitive functioning and memory formation. Observational studies have shown that sleep issues are associated with cognitive decline Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source and dementia. However, these studies do not prove a cause-and-effect relationship. Although more research is needed to better understand sleep and dementia risk, there are many proven steps you can take to improve your sleep.

What Can Help Someone With Dementia Sleep Better?

Sleep hygiene is the primary treatment for sleep concerns in people with dementia. Sleep hygiene is a collection of practices and environmental considerations that promote good sleep quality. The following sleep hygiene tips may help a person with dementia improve their sleep patterns:

• Maintain a regular schedule: Setting predictable wake and sleep times Trusted Source Medline Plus MedlinePlus is an online health information resource for patients and their families and friends. View Source may help to synchronize circadian rhythm in people with dementia. Create a bedtime routine that involves quiet, soothing activities before bed. Television and electronic devices can be stimulating and emit blue light that interferes with sleep, so try avoiding these activities before bed.
• Limit naps: Napping during the day can decrease sleepiness at night, so it may help to discourage napping or limit the practice to one nap lasting less than 30 minutes Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source .
• Engage in physical exercise: Exercising in the hour before bedtime can negatively affect sleep. However, getting exercise early in the day can lead to better sleep at night Trusted Source National Institutes on Aging (NIA) NIA leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. View Source . It also reduces napping and supports overall health.
• Schedule social activity: A research study found that people with dementia who participated in one to two hours of social activity per day showed improved nighttime sleep Trusted Source Wiley Online Library Wiley Online Library is one of the largest and most authoritative collections of electronic journals published by Wiley, as well as a vast and growing collection of reference works and other books. View Source .
• Add light exposure: Light is a key regulator of circadian rhythm, so if possible, getting natural light during the day can help with sleep at night. If access to natural light is limited due to weather or other factors, indoor bright light therapy may help.
• Avoid stimulants: It’s best to avoid caffeine, alcohol, and nicotine if possible. Additionally, some medications used to manage dementia can interfere with sleep, so talk with a doctor about the best time of day to administer medications.
• Treat pain and sleep disorders: If a person with dementia is dealing with pain, a sleep disorder, or depression, treating the condition may improve sleep. A doctor can help with exploring treatment options.
• Create a calming bedroom environment: A dark, quiet, comfortable bedroom promotes sleep. Some people with dementia benefit from having well-loved objects near their bed. If total darkness is not calming, add night lights to create a sense of security.

Some of these sleep hygiene practices may be difficult for someone with dementia. For example, it may not be possible to control the bedroom noise level in a nursing home or assisted living facility. Consider adding a white noise machine to mask outside noise. A person with dementia may also have a difficult time maintaining a regular bedtime due to napping or varied daily activities, but keeping wake time consistent can still help to stabilize the circadian rhythm. A physician or sleep specialist is in a good position to provide individualized sleep hygiene recommendations for a specific situation.

Medications for Dementia

Medications are seen as a last-resort option for people with dementia. The risks of sleep aids include increased confusion, sedation, and risk for falls or injury. Be sure to speak with a doctor before giving a sleep aid to a person with dementia.

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