What causes RLS? In July of 2007, researchers discovered a gene variant for RLS, which helps explain why it may be traced through generations in families. Researchers believe this gene increases one’s risk for a type of hereditary RLS, known as primary or familial RLS. Is there a cure for RLS? There is currently no cure for RLS. However, in most cases RLS symptoms can be controlled through lifestyle changes, such as diet and exercise, and medical treatments as appropriate.